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Renew E is a unique tocopherol-free, tocotrienols-only product, featuring tocotrienols sourced from the annatto tree. Annatto is the richest known source of tocotrienols, containing 100% tocotrienols (90% delta-isomers and 10% gamma-isomers), with no tocopherols. Renew E contains 300 mg per softgel of delta/gamma tocotrienols. Commercial vitamin E supplements are typically rich in tocopherols and low or absent in tocotrienols; however, tocotrienol fractions have unique beneficial effects across a variety of tissues that make them desirable for supporting many aspects of health. Research indicates that tocopherols — especially alpha-tocopherol — may interfere with key clinical effects of tocotrienols, so it may be best to take tocotrienols alone, without tocopherols.